Guide to Current Research in Victorian Universities Department of State and Regional Development
Medical Biotechnology 2001 Contents Search Previous Next

Peter MacCallum Cancer Institute

http://www.pmci.unimelb.edu.au/
Contact Details

The Peter MacCallum Cancer Institute is a comprehensive specialist oncology centre providing cancer services at its central site in Melbourne and through external clinics and satellites throughout Victoria.

The Institute aims to provide facilities and resources of the highest quality for diagnosing and treating cancer, for cancer research, and for related education and training.

Peter MacCallum Cancer Institute laboratories carry out research in the areas of:

  • cancer biology
  • cancer genetics
  • cell cycle control
  • cell cycle proteolysis
  • cellular proliferation
  • cellular radiation
  • differentiation and transcription
  • DNA repair
  • haemopoiesis stem cell biology
  • microscopy
  • molecular oncology
  • molecular radiation biology
  • multi-drug resistance
  • oncogene
  • pharmacology and developmental therapeutics
  • signal transduction
  • surgical oncology

 

http://www.pmci.unimelb.edu.au/research/index.asp
[ Australian Science at Work Entry ]

Genes that regulate breast cancer metastasis
Chief Researcher: Anderson Dr R
Sponsor: US Army Breast Cancer Research Program
Current Status: Ongoing
Descriptors: CDNA MICROARRAYS; METASTASIS--ANIMAL MODEL;--BONE
Research Field Classification: 270201 Gene Expression


Role of Hsp70 in stress-induced apoptosis
Chief Researcher: Anderson Dr R
Current Status: Ongoing
Descriptors: APOPTOSIS--RESISTANCE; CELL--TUMOUR; MECHANISM; PROTEIN BIOCHEMISTRY
Research Field Classification: 320305 Medical Biochemistry: Proteins and Peptides


Defining aspects of the mechanism of ionising radiation-induced DNA rearrangement in mammalian cells
Chief Researchers: Radford I, Forrester H
Sponsor: Anti-Cancer Council of Victoria
Duration: -2002
Descriptors: BIOLOGY--RADIATION; CELL DEATH; CHROMOSOME ABERRATIONS; DNA--REARRANGEMENT


Clonality of epithelial neoplasms using X-inactivation mosaic mice
Chief Researcher: Beshay V (PhD)
Supervisor Waring Assoc Prof
Duration: -2001
Descriptors: ANIMAL MODEL--MOUSE; CANCER; CLONALITY
Research Field Classification: 270803 Transgenesis


Novel approaches for activating and expansion of gene-engineered T cells in vivo
Chief Researchers: Haynes N, Snook M
Supervisors: Darcy Dr P, Smyth Dr M
Sponsor: Anti-Cancer Council of Victoria
Duration: 2001 - 2003
Descriptors: GENE--ENGINEERING; T CELLS
Research Field Classification: 320206 Tumour Immunology


Analysis of the molecular functions of perforin: A critical role in tumor immunosurveillance
Chief Researchers: Gouel C, Cretney E, Markby J
Supervisors: Trapani Dr J, Smyth Dr M
Duration: 2000 - 2002
Descriptors: CELLS--KILLER; PERFORIN
Research Field Classification: 320206 Tumour Immunology


The role of TRAIL in immunity
Chief Researcher: Cretney E
Supervisor: Smyth Dr M
Duration: -2000
Descriptors: METASTASIS; TUMOR--NECROSIS FACTOR
Research Field Classification: 320206 Tumour Immunology


The role of NKT cells and NK cells in tumor immunosurveillance
Chief Researcher: Crowe N
Supervisor: Smyth Dr M
Duration: -2000
Descriptors: CELLS--KILLER; IMMUNE NETWORKS
Research Field Classification: 320206 Tumour Immunology


Natural killer cell specific proteins and functions
Chief Researchers: Kelly J, Street S
Supervisor: Smyth Dr M
Duration: 1999 - 2003
Descriptors: CELLS--KILLER; GRANZYMES
Research Field Classification: 320206 Tumour Immunology


The role of multi-drug resistance protein in apoptosis
Chief Researchers: Tainton K, Ruefli A
Supervisors: Smyth Dr M, Johnstone Dr R
Sponsor: Anti-Cancer Council of Victoria
Duration: 1999 - 2003
Descriptors: APOPTOSIS; DRUG-RESISTANCE
Research Field Classification: 320206 Tumour Immunology

 


Coordination of transcription repression mediated by the MYC-antagonist MAD1, with other transcriptional regulators that mediate withdrawal from the cell cycle
Chief Researcher: Poortinga Dr G
Supervisor: McArthur Dr G
Current Status: Ongoing
Descriptors: CELL CYCLE; GENE--EXPRESSION;--TRANSCRIPTION
Research Field Classification: 270201 Gene Expression


Genes that function downstream of c-MYC to inhibit cellular differentiation and promote progression from G0 into S-phase of the cell cycle
Chief Researcher: Warner Dr B
Supervisor: McArthur Dr G
Current Status: Ongoing
Descriptors: CELL--CYCLE;--DIFFERENTIATION
Research Field Classification: 270205 Genetic Development


Genes that function downstream of MAD1 to inhibit progression from G1 into S-phase of the cell cycle
Chief Researcher: Deans A
Supervisor: McArthur Dr G
Current Status: Ongoing
Descriptors: CELL--CYCLE;--DIFFERENTIATION; GENE--TRANSCRIPTION
Research Field Classification: 270205 Genetic Development


Mechanisms of cellular differentiation and cell cycle withdrawal mediated by retinoids in granulocytes
Chief Researcher: Wakerley C (B Pharm)
Supervisor: McArthur Dr G
Current Status: Ongoing
Descriptors: CELL--CYCLE;--DIFFERENTIATION; GENE--TRANSCRIPTION
Research Field Classification: 270205 Genetic Development


Molecular mechanisms of interactions between loss of function of BRCA1 and loss of function of p27KIP1
Chief Researcher: Deans A
Supervisor: McArthur Dr G
Current Status: Ongoing
Descriptors: CANCER--BREAST; CELL--CYCLE
Research Field Classification: 270205 Genetic Development

 

Pharmacology and Developmental Therapeutics Unit

Clinical anti-cancer drug development
Chief Researchers: Ellis A (MSc), Stokes K (BSc Hons)
Supervisor: Webster Dr L
Current Status: Ongoing
Descriptors: ACCREDITATION--GLP; DRUG--ANALYSES;--PHARMACOKINETICS


Anti-cancer drug action
Chief Researcher: Cullinane C (PhD)
Supervisor: Webster Dr L
Current Status: Ongoing
Descriptors: BIOCHEMICAL--MODULATION; DRUG--MECHANISM


Pre-clinical anti-cancer drug development
Chief Researcher: Kleinschmidt M (BSc Hons)
Supervisor: Webster Dr L
Current Status: Ongoing
Descriptors: DRUG--ANIMAL ANTI-TUMOUR;--PHARMACOKINETICS;--QUANTITATION; IN VITRO TESTING
Research Field Classification:
320501 Pharmaceutical Sciences and Pharmacy

 

Trescowthick Research Laboratories
Differentiation and Transduction Laboratories

Colon cancer and development
Chief Researcher: Ramsay Dr R
Current Status: -2005
Descriptors: CELL--STEM; GENE--TRANSCRIPTION; ONCOGENE
Research Field Classification: 320304 Medical Biochemistry: Nucleic Acids

 

Gene Regulation Laboratory

Function and expression of interferon inducible proteins
Chief Researcher: Johnstone Dr R
Sponsor: Wellcome Trust
Current Status: Ongoing
Descriptors: CANCER--TUMOR; CELL--DIFFERENTIATION; GENE--TRANSCRIPTION


Characterisation of the multidrug resistance protein, P-glycoprotein
Chief Researcher: Johnstone Dr R
Sponsor: Anti-Cancer Council of Victoria
Current Status: Ongoing
Descriptors: CANCER--TUMOR; GENE--REGULATION; PHARMACEUTICALS--DRUGS

 

Immune Signalling Laboratory

Immune signalling
Chief Researchers: Ludford-Menting M, Crimeen B, Pederson N
Supervisor: Russell Dr S
Sponsor: Wellcome Trust
Current Status: Ongoing
Descriptors: CANCER--TUMOR SUPPRESSOR; MEMBRANE; RECEPTOR; SIGNALS
Research Fields Classifications: 320202 Cellular Immunology
270206 Genetic Immunology
320203 Humoral Immunology and Immunochemistry

 

Protein Chemistry Laboratory

The role of the Akt proto-oncogene in ovarian cancer
Chief Researcher: Cristiano B (PhD)
Supervisor: Pearson Dr R
Current Status: Ongoing
Descriptors: CANCER--TUMOUR; ONCOGENE; SIGNAL TRANSDUCTION
Research Field Classification: 320305 Medical Biochemistry: Proteins and Peptides


Characterisation of a novel regulatory pathway activating p70s6k, an important enzyme in cell cycle progression
Chief Researcher: Hannan Dr K (Post Doctoral fellow)
Supervisor: Pearson Dr R
Sponsor: Australian Research Council
Duration: 2001
Descriptors: CANCER--TUMOUR; RIBOSOME; SIGNAL TRANSDUCTION
Research Field Classification: 320305 Medical Biochemistry: Proteins and Peptides


Novel signalling pathways involving the Akt proto-oncogene
Chief Researcher: Conus Dr N M (Post Doctoral fellow)
Supervisor: Pearson Dr R
Current Status: Ongoing
Descriptors: ONCOGENE; TUMOUR; SIGNAL TRANSDUCTION
Research Field Classification: 320305 Medical Biochemistry: Proteins and Peptides


Role of the protein kinase Akt during the cell cycle
Chief Researcher: Trinh T L (Hons)
Supervisor: Pearson Dr R
Duration: 2001
Descriptors: CELL--CYCLE; ONCOGENE; SIGNAL TRANSDUCTION
Research Field Classification: 320305 Medical Biochemistry: Proteins and Peptides


Isolation and identification of novel substrates of the Akt protein kinase
Chief Researcher: Griffiths J (PhD)
Supervisor: Pearson Dr R
Current Status: Ongoing
Descriptors: CHEMISTRY--PROTEIN; ONCOGENE; SIGNAL TRANSDUCTION
Research Field Classification: 320305 Medical Biochemistry: Proteins and Peptides

 


Published by the Australian Science and Technology Heritage Centre on AustehcWeb, February 2002
WWW edition
[ Top of Page | Contact Details | Search | Previous | Next | List of Guides ]